PRA1 promotes the intracellular trafficking and NFB signaling of EBV latent membrane protein 1
نویسندگان
چکیده
Hao-Ping Liu, Chih-Ching Wu and Yu-Sun Chang* Institute of Microbiology and Immunology, National Yang Ming University, Shih-Pai, Taipei, Taiwan, Republic of China, Proteomics Core Laboratory of Chang Gung Molecular Medicine Research Center, Chang Gung University, Kwei-Shan, Taoyuan, Taiwan, Republic of China and Graduate Institute of Basic Medical Sciences, Chang Gung University, Kwei-Shan, Taoyuan, Taiwan, Republic of China
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EBV LMP2A affects LMP1-mediated NF- B signaling and survival of lymphoma cells by regulating TRAF2 expression
A mechanism used by Epstein-Barr virus (EBV) for in vitro transformation of B cells into lymphoblastoid cell lines (LCLs) is activation of the NFB pathway, which is largely mediated by the EBV latent membrane protein 1 (LMP1). LMP1 is coexpressed with LMP2A in many EBV-associated lymphoid malignancies. Since inhibition of NFB leads to apoptosis of EBV-infected LCLs and lymphoma cell lines, we s...
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